Serotonin (5-HT) correlates with Adiponectin in overweight patients

Claus Muss1, Thomas Endler2
1International Research Group for Applied Preventive Medicine (I-GAP), Vienna, Austria 2Labor Endler, Vienna, Austria

Korespondenční autor: Claus Muss (

ISSN 1804-7181 (On-line)

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Submitted:20. 3. 2013
Accepted: 16. 7. 2013
Published online: 30. 12. 2013


We examined the relationship of two neurohormones with neuroendocrine impact (serotonin /5-HT/ and adiponectin) under standardized clinical conditions in an overweight cohort. Adiponectin was measured in serum and Serotonin was determined in the second morning urine samples. Serotonin correlated positively with adiponectin in our investigation Srho (+0.303; p=0.03). As high adiponectin level corresponds with a low risk of Insulin resistance our findings refer to possible improvement of prediabetic conditions in overweight patients tracking peripheral serotonin circulation. Further clinical evidence is mandatory to verify the effects of 5-HT in patients with metabolic syndrome.

Keywords: serotonin (5-hydroxytryptamine – 5-HT); adiponectin; overweight patients; insulin secretion


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